Sunday, June 5, 2011

Parkinson's Disease

Parkinson neurodegenerative diseases in which certain nerve cells in the brain in the area, the substantia nigra die or violation is called is displayed. These nerve cells responsible for producing dopamine, a smooth, coordinated muscle movements throughout the body. disease was originally called "shaking palsy" in 1817 by British doctor James Parkinson defined in accordance with which it is now called.
Symptoms of Parkinson's disease seems to stop after about 80% of dopamine-producing nerve cells work properly. Symptoms include tremors, slow movements, difficulty balancing and tight or rigid motion and can lead to a stiff hand, shuffling of feet when walking, boring, stiff facial expression, and depression. Parkinson's disease affects men and women, mostly people over 65 years. About 60.000 cases diagnosed each year in the United States.
  
There is no cure for Parkinson's disease, but some treatments can help slow the progression of the disease and its symptoms. Treatment usually replace the missing dopamine, and drugs for the disease often contain L-dopa, a precursor of the intermediate in the production of dopamine from the amino acid tryptophan. Other drugs may be used to inhibit or suppress neurotransmitter MAO-B, an enzyme that breaks down dopamine. Some operations can relieve symptoms in extreme cases.
Although these medications can significantly improve quality of life, can live for many people and their diseases without drugs.

  
was the number of genes involved in Parkinson's disease brought in connection with: Alpha-synuclein
    Parkin
    ubiquitin carboxy terminal hydrolase
    • DJ-1
    • SCA2
    • GIGYF2
   Opening GIGYF2 just reported (March 2008). More is known about the first 5 genes, each of which plays a role in the abnormal processing of protein cells. For example, in cells, proteins, which were covered with ubiquitin for destruction are marked. Mutations in the genes for ubiquitin carboxy terminal hydrolase and parkin cause is not certain ubiquitinated proteins and thus are not destroyed. This can cause damage and death of cells harvested when the proteins in cells.

    Using cells derived neutrophic factor is the treatment for the protection of the therapeutic success of some dopamine-releasing neurons showed. techniques of gene therapy using stem cells known as therapeutic cloning, also showed some promise as a treatment in dopamine production of enzymes in the brain are replenished using a viral vector that delivers the gene of the enzyme in the brain