Parkinson neurodegenerative diseases in which certain nerve cells in the brain in the area, the substantia nigra die or violation is called is displayed. These nerve cells responsible for producing dopamine, a smooth, coordinated muscle movements throughout the body. disease was originally called "shaking palsy" in 1817 by British doctor James Parkinson defined in accordance with which it is now called.
Symptoms of Parkinson's disease seems to stop after about 80% of dopamine-producing nerve cells work properly. Symptoms include tremors, slow movements, difficulty balancing and tight or rigid motion and can lead to a stiff hand, shuffling of feet when walking, boring, stiff facial expression, and depression. Parkinson's disease affects men and women, mostly people over 65 years. About 60.000 cases diagnosed each year in the United States. There is no cure for Parkinson's disease, but some treatments can help slow the progression of the disease and its symptoms. Treatment usually replace the missing dopamine, and drugs for the disease often contain L-dopa, a precursor of the intermediate in the production of dopamine from the amino acid tryptophan. Other drugs may be used to inhibit or suppress neurotransmitter MAO-B, an enzyme that breaks down dopamine. Some operations can relieve symptoms in extreme cases. Although these medications can significantly improve quality of life, can live for many people and their diseases without drugs.
was the number of genes involved in Parkinson's disease brought in connection with: Alpha-synuclein •Parkin •ubiquitincarboxyterminalhydrolase • DJ-1 • SCA2 • GIGYF2 OpeningGIGYF2justreported(March 2008).More is knownaboutthe first 5genes, eachof which plays arolein theabnormalprocessingof proteincells.For example,incells,proteins, whichwerecovered withubiquitinfordestructionare marked.Mutations in thegenesforubiquitincarboxyterminalhydrolaseandparkincauseis notcertainubiquitinatedproteinsandthusare notdestroyed.This cancause damageanddeathof cellsharvestedwhen theproteinsin cells.
Usingcellsderivedneutrophicfactoris thetreatmentfor the protection ofthe therapeuticsuccessof somedopamine-releasingneuronsshowed.techniquesof genetherapyusingstemcells knownastherapeutic cloning,alsoshowedsomepromiseas atreatmentindopamineproduction ofenzymesinthe brainare replenishedusing aviral vectorthatdeliversthe geneof the enzymein thebrain